Nephrotic syndrome is caused by an increase in the permeability of the glomerular basement membrane, so that any damage to the glomeruli can cause nephrotic syndrome.
Nephropathy syndrome is mainly secondary or primary, nephrotic syndrome, the main pathogenesis is related to the immune mechanism.
infection
Bacterial infections can cause nephrotic syndrome, such as streptococcal infection, leprosy, syphilis, tuberculosis. There are viruses infected with cytomegalovirus, hepatitis B, HIV and other parasites can also cause disease
Drugs and allergies
Silver, penicillamine, probenecid and trimethoprim and other drugs, may lead to nephropathy syndrome. Allergic reactions caused by pollen, vaccines, antitoxins, etc., can also lead to this disease.
Tumor
Tumors in the lungs, stomach, breast, thyroid, etc., may lead to nephropathy syndrome
Systemic disease
Systemic diseases, such as systemic lupus erythematosus, dermatomyositis, allergic purpura, may cause changes in glomeruli, then they may lead to nephropathy syndrome.
Genetic disease
These include congenital nephrotic syndrome, Alport syndrome, Fabry disease.
These are the common causes of secondary nephrotic syndrome, and in our case, most of the secondary nephrotic syndrome is autoimmune disease, diabetic nephropathy and Henoch-Schonlein purpura nephritis.
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