Nephrotic syndrome is a clinical diagnosis, as long as a large amount of proteinuria (24 hours greater than 3.5 grams), hypoproteinemia (albumin less than 30 grams) two conditions diagnosed with nephrotic syndrome. But from the modern medical point of view is not the case, and now our current medical diagnosis of the disease is from the cytopathological point of view, that pathological diagnosis is glomerular capillary epithelial cell damage, because the healthy epithelial cells is kidney Small ball filter barrier an important part of the glomerular filtration barrier function is to block and bind the protein to stay in the body for human nutrition needs. So as long as the protein leaked we say that glomerular capillary epithelial cell disease.
What Are the Causes of Relapse in Nephrotic Syndrome
Why is kidney disease syndrome?
From the renal biopsy is not difficult to see that this is a small pathological changes, small lesions is a pathological name of kidney disease, which can also explain that this is the most light type of nephrotic syndrome, so that after treatment, Yes, it can be completely cured. But why have this disease? Generally due to their own immune deficiency, mucosal infection in the long-term sustained effect on the glomeruli, destruction of the glomerular self-regulation function, the formation of a large number of immune complexes in the blood circulation of glomeruli, to promote glomerular local Microcirculation disorders, kidney cells in the inherent damage, resulting in normal renal cell damage, start kidney fibrosis. This functional cell is epithelial cells, podocyte fusion caused by vacuolar degeneration, swelling and necrosis and other results, so that the surface of the cell surface of the anion charge decreased or disappeared, the basement membrane negative charge, glomerular basement membrane barrier function damage, protein Leakage, so called glomerular epithelial cells and podocytosis. The presence of a large number of proteinuria also shows that renal tubular reabsorption dysfunction, that is, a large number of protein into the renal tubular, due to proximal renal tubular reabsorption overload, damage the wall of the lysosome, so that activity increased into the epithelial cells Leading to damage to epithelial cells. After injury, renal tubular epithelial cells attract inflammatory cells into the renal interstitial, causing interstitial inflammation.
Nephrotic syndrome (minimal change nephropathy) how to treat?
Our treatment is mainly from the kidney pathology to start treatment, then from the pathological point of view, that is, each step of the pathogenesis of the deterioration of the chain cut off, in general, there are four steps:
Why is Nephrotic Syndrome Easy to Relapse
1, expansion of blood vessels, expansion of renal artery at all levels to improve renal microcirculation, increase renal effective perfusion, improve the damaged kidney ischemia and hypoxia, accelerate the repair of damaged kidney.
How To Treat Nephrotic Syndrome Without Making It Relapse
2, anti-inflammatory effect, inhibition of inflammatory mediators, cytotoxic factors, and its renal toxicity inactivation, to avoid new damage to the new kidney tissue.
3, anticoagulation, anti-thrombosis, because a long time hypoglycemia plasma colloid osmotic pressure drop is easy to form thrombosis, it must be anticoagulant therapy, inhibition of platelet adhesion and aggregation.
4, the degradation of the role of degradation of the inflammatory reaction to clear the formation of immune complexes, repair damaged glomerular capillary epithelial cells, to avoid recurrent.So that simple Western medicine treatment and simple treatment of traditional Chinese medicine can not do, have their own limitations, the best measure is the organic combination of Chinese and Western medicine treatment, so as to achieve one step in place to avoid repeated.
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Understanding Kidney Disease
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