Kidney disease proteinuria hazards

Nephrotic patients is a common symptom is the emergence of proteinuria, most of these symptoms occurred in patients with chronic nephritis and nephrotic syndrome patients. Protein is a necessary substance in the human body, the occurrence of proteinuria means that patients with a large number of proteins with urine discharge, affecting the health of the body. So what is the risk of proteinuria in kidney disease? See how our experts are introduced.

Kidney disease, the risk of proteinuria: proteinuria mesangial toxicity, glomerular mesangial protein accumulation will continue to lead to mesangial cells are damaged, hyperplasia of mesangial matrix synthesis increased, and ultimately cause glomerular sclerosis. And glomerular apolipoprotein A and apolipoprotein B deposition will eventually cause glomerular sclerosis.

Kidney disease, the risk of proteinuria: proteinuria can cause renal failure, mainly due to its biological changes caused by tubule cells caused by non-adaptive response. According to the current data, the protein can directly regulate the function of small tube, change its growth characteristics and its cytokines and matrix protein phenotype expression, but also the release of PDGF, FN and MCP-1 on the basal side of the tubule, induced fibrosis process.

Kidney disease, the risk of proteinuria: proteinuria toxic effects will affect the proximal tubule, increased into the renal tubular epithelial cells within the amount of protein, thereby increasing the activity of lysosomes, which means that the protein lysosome overflow into the tubules Pulp, and then the damage caused by cell damage caused by inflammation and scar generation. There may be caused by interstitial hypoxia aggravated, leading to small tube cells hypoxia, to damage.

Proteinuria will not only make a lot of protein loss, there may damage the renal tubules, glomerular. And therefore must be effective in preventing and control work, to avoid the above described kidney disease proteinuria hazards, so as not to affect your healthy life.

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