1. infection: cold, tonsillitis, fever and other symptoms of the naked eye or urinary occult, infectious factors recurrent, leading to the occurrence of IgA nephropathy.
2. immune complex: IgA nephropathy in patients with glomerular mesangial areas of a large number of immune complex material, the combination of the two can lead to the formation of renal cells in the phenotype of the disease caused by the occurrence of disease.
3. Genetics: IgA nephropathy in patients with the incidence of investigation, some patients with IGA nephropathy will occur family aggregation phenomenon, indicating that IgA nephropathy to a certain extent genetic predisposition.
4. Inflammation: The renal glomerular mesangial cells of the patient are stimulated by inflammatory damage to produce inflammatory factors, resulting in a large number of immune complexes in the patient's kidney, eventually leading to disease.
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