Nephrotic syndrome hormone use precautions

(1) initial treatment stage:Hormone treatment of nephrotic syndrome efficacy, and the dose has a certain relationship. In the newly diagnosed case, the initial treatment phase dose should be large enough to induce rapid remission, adult prednisone dosage should be 1 mg / kg per day, in individual patients, if necessary, to 1.5mg / kg per day. It is reported that 2 to 13 years old children, prednisone dose should be 2 to 2.5mg / kg per day. Children younger age, the greater the amount of prednisone needs. But the daily dosage of hormones, should not exceed 80mg. If the patient's liver dysfunction, it is not appropriate to use prednisone, but should be changed to strong pine dragon, the latter dose and prednisone the same. The application of hormones to the morning meal as well.

What Is the Prevention of Nephrotic Syndrome

(2) reduction treatment stage:Usually with high-dose hormone 8 weeks will have to be reduced, the weekly reduction of 10% of the original daily dose, adults generally 5m g per week. ① If the 8-week high-dose treatment is not improved, or even worse, in the careful removal of the same time there are factors affecting the efficacy of infection, etc., it is estimated that continued medication will not be effective (hormone ineffective), should quickly reduce the dose, Use, if conditional, it is best to send a higher hospital for renal biopsy. ② if the treatment of nephrotic syndrome after partial relief (proteinuria <3g / d or more than half of the original reduction, edema and other symptoms have been reduced), the hormone withdrawal to a small dose (adult daily 0.5mg / kg, Children for daily 1mg / kg), changed to two days dose, the next day morning Dayton clothing. ③ such as high-dose hormones soon or not enough 6 weeks to get relief, after remission and then the original dose consolidation for 2 weeks, can be reduced. Such as small lesions of kidney disease, 90% of children in 4 weeks after the complete remission, it is usually taken 4 weeks later, and then take 2 weeks, you can enter the reduction phase. Adults are slow to slow down, usually need to apply hormones for 8 weeks, in order to identify the hormone on the case of nephrotic syndrome is effective. Application of hormone general treatment should not be more than 3 months, increase the dose of hormones and prolong the course of treatment, must be cautious.
What Should I Do When I Have a Cold with Nephrotic Syndrome

From large doses to small doses (adults about 0.5mg / kg per day, children for daily 1mg / kg), should be changed to two days of the dose, every morning morning service. Withdrawal to a small dose, the adverse reactions of hormones will be greatly reduced, this time depending on the specific circumstances, for longer-term continuous treatment or continue to reduce. If the decision to continue to reduce, this time the reduction should be emphasized very slowly, the smaller the dose, the reduction should be slower. Only in this way can we reduce the recurrence of nephrotic syndrome. The reduction process, at least have to go through more than 1 month.

What Are Treatment for Children with Nephrotic Syndrome

(3) continuous treatment phase① the first large dose of hormone therapy, only partial remission, according to the above method of reduction, to a small dose (adults every other day 1mg / kg, children every other day 2 ~ 2.5mg / kg), can take 6 months or Longer than usual, usually with this small dose of hormones, the adverse reactions are not large; if the patient in the small dose of continuous treatment, access to complete remission, after the remission, according to the original and then served for 4 weeks, then, very slowly and regularly Reduction, to the maintenance of the amount, depending on the patient's specific circumstances, with the maintenance of a period of time, and then gradually reduced to the withdrawal.

Treatments for Proteinuria in Children with Nephrotic Syndrome

② hormone-sensitive, faster access to complete remission of the case, usually according to the above reduction to the maintenance dose of hormones, that is, strong loose morning clothes 0.4mg / kg, this is the physiological requirements, little adverse reactions, about Served for 4 months or longer, and then slowly reduced and stopped. 
③ some patients in the initial treatment was completely relieved, but short-term (<6 months) recurrence, or even reduced to a certain extent, the degree of recurrence (ie, hormone-dependent), reusable hormone therapy, and hormone Routine reduction to maintenance dose of continuous treatment, the sustainable medication 12 to 18 months. 

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