Today's society, diabetes is we are more familiar with it, but diabetes has a high complication, in fact, diabetic nephropathy is now more common, the harm is relatively large, that in the end what causes the cause of diabetic nephropathy? Here to see a brief introduction to the experts:
Will Diabetes Finally Cause Diabetic Kidney Disease
1, hyperglycemia. Diabetic nephropathy and hyperglycemia are closely related to poor blood glucose control will accelerate the occurrence of diabetic nephropathy, good control of blood glucose can significantly delay its development, increased levels of hyperglycemia and glycosylation products can cause mesangial cell proliferation, extracellular Increased matrix, glomerular basement membrane thickening.Higher-than-normal Blood Sugar Levels Can Lead to Kidney Failure Over Time, Research Says
2, renal blood flow abnormalities. (1) glomerular basement membrane type Ⅳ collagen messenger sugar nucleic acid increased, so that the basement membrane thickening, and ultimately the formation of diffuse mesangial, nodular lesions, glomerular sclerosis occurred. (2) hyperglycemia, glomerular hyperperfusion, hyperfiltration, increased pressure across capillaries, expansion of mesangial cells, fusion of epithelial cell fossa and generation of dense droplets, glomerular epithelial cells from Base film off. (3) in the case of increased pressure, protein filtration increased, can also be deposited in the mesangial area and glomerular basement membrane, promote matrix proliferation, the formation of a vicious cycle, and can cause nodular and diffuse glomerulosclerosis TheDiabetic Kidney Disease: How Does it Develop and Progress
3, genetic factors. Diabetes mellitus disease is also associated with family genetic relationship, in some family history of diabetes with diabetes, the incidence of diabetic nephropathy was significantly higher than the family history of patients without hypertension, in addition, between different races of diabetic nephropathy The incidence rate is also different.
Is Kidney Failure Common Among Diabetic People
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