First, the primary factor
(1) genetic factorsPediatric nephrotic syndrome in siblings and twins in the incidence of about 2% -6%. Sharpies (Shapelles 1985) investigated the incidence of hormone-sensitive nephropathy children born in Birmingham, England, among the Asian, African and European groups. The highest incidence was found in Asia, with an annual incidence of 16/10 million children, the other two groups were 2.6 / 10 million, 3.1 / 10 million children. Feehally reported that the incidence of children with minimal changes in nephrotic disease in Leicester, UK, was significantly higher in Asia than in non-Asian children, at 9.4 / 100,000 and 1.3 per 100,000 children, respectively. The Asian children living in Leicester, England, are mostly Indians who speak Gujarati, and some of the people who speak the Punjabi Sikh or Islam. The authors argue that racial and environmental differences are two important factors that may increase the susceptibility of minimal changes to nephropathy.
Prognosis of Nephrotic Syndrome in Children
(2) - allergic body qualityThe
research unit, the children of various kidney disease HLA antigen to
study, that NS allergic factors accounted for 35.3%, the control group
was 6.7%, which is related to HLA-B40. There have been reports of NS metamorphosis history accounted for 40%.(3) immune mechanismNS is associated with humoral immunity, immune complex formation, and cellular immunity. Elzouki (Ai Luke 1984) survey report, the Arab children with primary nephrotic syndrome incidence of 11.6 a few. Million children. The higher incidence of the disease may be related to climate,
geography, the type of child infection, the genetic characteristics of
the Arab population, many factors may affect the immune pathogenesis of
kidney disease.What is Permanent Solution for Nephrotic Syndrome In Children
Second, secondary factors(A) infection1, bacterial infection: streptococcal infection after nephritis, bacterial endocarditis, shunt nephritis, syphilis, leprosy, chronic pyelonephritis with reflux nephritis. 2. Viral infection; hepatitis B, infectious mononucleosis, Cy-tomegalovirus, post-vaccine nephritis.3. Parasitic infections: three malaria, Toxoplasnosis, Helminthic (sehistoso-miasis).(B) drugsPoisoning, allergic, organic or inorganic mercury, organic gold, bismuth, silver, penicillamine, heroin, probenecid, trimethophenone, Captopril, bee sting, snake venom, pollers, antitoxin or vaccine allergy.
Many Possible Causes of Nephrotic Syndrome
(C) new creaturesSolid tumor (Careinoma or sarcoma): lung, colon, stomach, breast, kidney, thyroid, ovarian and other tumors, wilms tumor. Lymphoma and leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma.(D) Department of 6L diseaseSystemic lupus erythematosus, mixed connective tissue disease, Sjogren's syndrome, rheumatoid arthritis, allergic purpura, necrotizing vasculitis, polyarteritis, cryoglobulinemia, amyloidosis, sarcoma.(E) metabolic diseasesDiabetes, mucus edema.(F) hereditary diseaseAlport, Syndrome, Fabry's Disease, Nail-patella Syndrome, Congenital Nephrotic Syndrome (Finnish), familial nephrotic syndrome, sickle red blood cell anemia.(G) otherPregnancy toxemia, chronic renal allograft rejection, primary malignant renal sclerosis, renal artery stenosis, chronic ulcerative colitis.
