IgA nephritis etiology

IgA is an immunoglobulin, an antibody belonging to a human. Abnormal circumstances, in the kidney by a variety of inflammatory response to stimulate and other factors, leading to excessive deposition of IgA in the renal glomerular mesangial area and other parts, together with the formation of immune complex antigen, resulting in pathological damage of renal structure, caused by a series of clinical Symptoms, known as IgA nephropathy. The clinical manifestations of recurrent nausea hematuria or microscopic hematuria, may be associated with varying degrees of proteinuria, some patients can be severe high blood pressure or renal insufficiency. There are many reasons for the induction of IgA nephritis, the following are the three main reasons.

How Does IgA Nephropathy Affect Kidneys
1. Infection: This is a major cause of the disease, where the infection is a virus and a bacterial infection. The most common is the upper respiratory tract infection, urinary tract infection, skin infections, etc., in daily life, we should avoid the occurrence of infection, so as not to cause IgA nephropathy.
Life Expectancy with Creatinine 6.2 for IgA Nephropathy Patients

2. Immune disorders: the cause of the disease there are many, immune imbalance is one of the most common one reason. Some patients with serum can be detected in the pathogenic rheumatoid factor, indicating the immunoglobulin non-mucous source, in addition to peripheral blood lymphocytes in patients found IgA-specific auxiliary T cells increased, indicating that the occurrence of IgA nephropathy And immune abnormalities.

What does a GFR 48 Mean in IgA Nephropathy

3. Genetics: In addition to the above two reasons, there is a often overlooked reason is genetic. This is based on the conclusions of the study, the disease has a high incidence of the region, and in some blood-related family history of the higher incidence of genetic studies confirmed that the occurrence of the disease and human genetic inheritance has a certain relationship.

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