In recent years, the pathogenesis of kidney disease research has made great progress. Although little is known about etiology and predisposing factors, it has been confirmed that glomerular disease is mostly immune-mediated diseases caused by inflammatory diseases or metabolic abnormalities.
The use of cell biology and molecular biology methods in vitro experimental studies have been confirmed in a variety of chronic progressive nephropathy in the development and development process, not only the local infiltration of inflammatory cells can release inflammatory mediators, stimulated activation of the kidney inherent Cells can also stimulate the neighboring cells through autocrine or paracrine form to produce more inflammatory mediators, cytokines, growth factors, etc., to promote the continuous progress of inflammatory lesions, leading to glomerular sclerosis and tubulointerstitial fibrosis The
In addition, a large number of proteinuria, hyperlipidemia, hyperglycemia and a variety of metabolic abnormalities caused by abnormal changes in renal cell abnormalities in the role of chronic disease progression is also more and more attention. Researchers have noted that local inflammatory responses, cell phenotypic changes, abnormal cell proliferation, and extracellular matrix synthesis and degradation imbalance caused by various inflammatory mediators or abnormal metabolism on renal innate cells are pathophysiological processes of these diseases In the study of the changes in the pathogenesis of kidney disease and its understanding of the pathogenesis of kidney disease.
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