IgA nephropathy, also known as Berger disease, is a special type of glomerulonephritis, mostly in children and young people, often before the onset of upper respiratory tract infection, the lesion is characterized by glomerular mesangial proliferation, with immunofluorescence can be seen There is IgA deposition in the area.
The pathogenesis of IgA nephropathy
IgA nephropathy is the most common pathogenesis of glomerular mucosal immune function defects. Due to mucosal immune function defects, a large number of IgA deposition in the glomerular mesangial area. Combined with IgA nephropathy in patients with normal blood lack of glycosylation, making glycosylation can not be combined with IgA, resulting in a large number of IgA deposition. IgA deposited in the glomerular mesangial area causes kidney innate cells to be damaged, leading to the occurrence of renal disease. Among them, the damaged kidneys inherent cells with glomerular mesangial cells are important initiators of renal disease.
In addition, due to the large accumulation of IgA, combined with the transformation of the phenotype of the kidney cells, making the glomerular capillaries narrowing, intravascular infusion pressure reduction, glomerular effective filtration rate decreased gradually gradually , Renal vascular fibrosis, sclerosis. Due to IgA accumulation in the glomerular, making the occurrence of microcirculation within the kidney, microthrombosis, myofibroblast proliferation, the occurrence of these conditions will further promote glomerular fibrosis, sclerosis.
Chinese medicine treatment of IgA nephropathy
For the time being, the most effective way to treat IgA nephropathy is to use traditional Chinese medicine treatment, Western medicine can be timely control of patients often appear in clinical inflammatory response, but the root causes of inflammatory reactions such as kidney within a variety of toxic substances can not To carry out a comprehensive clean-up; and active substances in traditional Chinese medicine will produce a variety of toxic substances to carry out a more thorough removal of toxic substances, and pay more attention to the repair of renal function.
As the prognosis of IgA nephropathy mainly with a large number of proteinuria, hypertension, renal dysfunction, glomerular sclerosis, interstitial fibrosis and renal arteriosclerosis related, so the treatment of IgA nephropathy should be based on the extent of the difference between these indicators treat.
IgA nephrotic treatment is focused on the protection of renal function, reduce proteinuria, control of hypertension, delay the progress of IgA nephropathy. Common drugs for the treatment of IgA nephropathy include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor antagonists (ARB), hormones, immunosuppressive agents, anticoagulant, antiplatelet aggregation and fibrinolysis, fish oil, etc. , In addition to the treatment of IgA nephropathy Many people often use the method for tonsil removal and traditional Chinese medicine.
The use of traditional Chinese medicine treatment of IgA nephropathy has certain advantages, it is through the syndrome differentiation to repair renal tissue, improve renal function, so that IgA nephropathy control. But to get a good effect, take some time. Because a few years or even ten years of chronic disease, it is impossible to cure overnight. Therefore, to remind patients with IgA nephropathy and patients, it is necessary to attach great importance to IgA nephropathy, active treatment, and not too impatient, to be patient treatment, until the complete recovery.
Your time is precious and so is your kidney health.
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